Biological Activity
Nap-FF (2-Naa-FF) is a cell penetrant dipeptide that self-assembly and adopt the β-sheet structures to tát size prion-like nanofibrils of small molecules (PriSM). PriSM of Nap-FF are selectively cytotoxic to tát gliomas cancer cells in a presence of stromal cells. PriSM of Nap-FF selectively accumulate in cancer cells, impedes the dynamics of cytoskeletal filaments, and induces apoptosis.
Chemical Information
| Molecular Weight | 480.55 |
| Formula | C30H28N2O4 |
| CAS Number | 946568-62-3 |
| Solubility (25°C) | DMSO: trăng tròn mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
Conversion of different model animals based on BSA (PMID: 27057123)
| Species | Mouse | Rat | Rabbit | Guinea pig | Hamster | Dog |
| Weight (kg) | 0.02 | 0.15 | 1.8 | 0.4 | 0.08 | 10 |
| Body Surface Area (m2) | 0.007 | 0.025 | 0.15 | 0.05 | 0.02 | 0.5 |
| Km factor | 3 | 6 | 12 | 8 | 5 | 20 |
| Animal A (mg/kg) = Animal B (mg/kg) multiplied by | Animal B Km |
| Animal A Km |
For example, to tát modify the dose of Compound A used for a mouse (20 mg/kg) to tát a dose based on the BSA for a rat, multiply trăng tròn mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.
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References
[1] Meiwen Cao, et al. Enzyme-Triggered Morphological Transition of Peptide Nanostructures for Tumor-Targeted Drug Delivery and Enhanced Cancer Therapy
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